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The presence of leuko-araiosis in patients with Alzheimer's disease predicts poor tolerance to tacrine, but does not discriminate responders from non-responders.

Abstract:

BACKGROUND: approximately one-third of patients with Alzheimer's disease (AD) respond favourably to the anticholinesterase tacrine, but the drug's usefulness is marred by a high incidence of side-effects. OBJECTIVE: to discover if AD patients with white matter low attenuation (WMLA) represents a subgroup that responds differently to tacrine from those with no WMLA. DESIGN: the results come from a combination of double-blind and open studies. Seventy-two AD patients prescribed tacrine in our c...

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Publication status:
Published

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Publisher copy:
10.1093/ageing/26.1.25

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Age and ageing
Volume:
26
Issue:
1
Pages:
25-29
Publication date:
1997-01-05
DOI:
EISSN:
1468-2834
ISSN:
0002-0729
URN:
uuid:25aa2bb4-251c-4857-a65f-94847a994a20
Source identifiers:
36050
Local pid:
pubs:36050

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