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Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study.

Abstract:

Background

Intravascular hemolysis is an intrinsic feature of severe malaria pathophysiology but the pathogenic role of cell-free hemoglobin-mediated oxidative stress in severe malaria associated acute kidney injury (AKI) is unknown.

Methods

As part of a prospective observational study, enrolment plasma cell-free hemoglobin (CFH), lipid peroxidation markers (F2-isoprostanes (F2-IsoPs) and isofurans (IsoFs)), red cell deformability, and serum creatinine were quanti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12879-017-2373-1

Authors


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Department:
Oxford, MSD, NDM, Tropical Medicine
Role:
Author
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Department:
Oxford, MSD, NDM, Tropical Medicine
Role:
Author
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Publisher:
BioMed Central Publisher's website
Journal:
BMC Infectious Diseases Journal website
Volume:
17
Issue:
1
Pages:
313
Publication date:
2017-04-05
Acceptance date:
2017-03-30
DOI:
ISSN:
1471-2334
Pubs id:
pubs:692261
URN:
uri:25a8349f-8f5a-4f65-a25d-2b6a60789f8b
UUID:
uuid:25a8349f-8f5a-4f65-a25d-2b6a60789f8b
Local pid:
pubs:692261

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