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Total synthesis of spirastrellolide A methyl ester--part 1: Synthesis of an advanced C17-C40 bis-spiroacetal subunit.

Abstract:
Out of the blue: The marine macrolide spirastrellolide A is a potent and selective inhibitor of protein phosphatase 2A and a lead for anticancer therapies. A flexible and modular synthetic strategy has been developed with two routes for the construction of the DEF bis-spiroacetal subunit. The optimized Suzuki coupling approach results in the efficient preparation of a C17-C40 aldehyde that forms the cornerstone of the first total synthesis. (Chemical Equation Presented). © 2008 Wiley-VCH Verlag GmbH and Co. KGaA.
Publication status:
Published

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Publisher copy:
10.1002/anie.200705565

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
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Journal:
Angewandte Chemie (International ed. in English)
Volume:
47
Issue:
16
Pages:
3016-3020
Publication date:
2008-01-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:2599db74-4cd4-427c-b9fb-0aa7a59f3850
Source identifiers:
117840
Local pid:
pubs:117840

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