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A note on the power to detect transmission distortion in parent-child trios via the transmission disequilibrium test.

Abstract:

Transmission distortion refers to deviation from the normal 50:50 transmission of alleles from parents to offspring. Identification of genomic regions which undergo distortion is necessary for the correct interpretation of linkage and association studies, since tests of linkage using affected relative pairs and family based tests of association will yield spurious results in the presence of transmission distortion. With the increasing availability of genome-wide high density SNP data (e.g. fr...

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Publication status:
Published

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Publisher copy:
10.1007/s10519-006-9087-2

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Behavior genetics
Volume:
36
Issue:
6
Pages:
947-950
Publication date:
2006-11-01
DOI:
EISSN:
1573-3297
ISSN:
0001-8244
Source identifiers:
33521
Language:
English
Keywords:
Pubs id:
pubs:33521
UUID:
uuid:2597d74e-6ac6-402b-ac23-acb2787cbbbb
Local pid:
pubs:33521
Deposit date:
2012-12-19

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