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11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.

Abstract:

Patients with cortisol excess, Cushing's syndrome, develop a classical phenotype characterized by central obesity, hypertension, and increased cardiovascular mortality. Whilst this observation points to the importance of glucocorticoids, circulating cortisol excess is rare and does not explain the pathogenesis of many common conditions. At a tissue specific level, the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) locally regenerates active cortisol from inactive cortisone am...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Journal:
Minerva endocrinologica
Volume:
30
Issue:
1
Pages:
37-46
Publication date:
2005-03-05
EISSN:
1827-1634
ISSN:
0391-1977
URN:
uuid:25819d09-d5a3-4eee-b327-a31af1ca0fcd
Source identifiers:
482103
Local pid:
pubs:482103

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