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The hypoxia response pathway and β-cell function.

Abstract:

β-cells sense glucose and secrete appropriate amounts of insulin by coupling glucose uptake and glycolysis with quantitative ATP production via mitochondrial oxidative pathways. Therefore, oxidative phosphorylation is essential for normal β-cell function. Multiple cell types adapt to hypoxia by inducing a transcriptional programme coordinated by the transcription factor hypoxia-inducible factor (HIF). HIF activity is regulated by the von Hippel-Lindau (Vhl) protein, which targets the HIFα sub...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Maxwell, PH More by this author
Withers, DJ More by this author
Journal:
Diabetes, obesity and metabolism
Volume:
12 Suppl 2
Issue:
SUPPL. 2
Pages:
159-167
Publication date:
2010-10-05
DOI:
EISSN:
1463-1326
ISSN:
1462-8902
URN:
uuid:257ba078-f5e8-4fc7-88c9-27ff1098c1b4
Source identifiers:
386667
Local pid:
pubs:386667

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