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THE GROWTH AND CHARACTERIZATION OF CRYSTALS OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) REVERSE-TRANSCRIPTASE

Abstract:

Extensive studies on the crystallization of HIV-1 reverse transcriptase (RT) have yielded several crystal forms, two of which show diffraction to minimum Bragg spacings of 6 Å or better. Type 1 crystals belong to the space group P212121 with unit cell dimensions a = 147 A ̊, b = 190 A ̊ and c = 182 A ̊. Crystal density measurement indicate a very high crystal solvent content of 77% consistent with the presence of two RT heterodimers (66k/51k) per crystallographic asymmetric unit. These crysta...

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Publication status:
Published

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Journal:
JOURNAL OF CRYSTAL GROWTH
Volume:
126
Issue:
2-3
Pages:
261-269
Publication date:
1993-01-05
DOI:
ISSN:
0022-0248
URN:
uuid:256f65ad-d412-44c6-8960-9e42efa5eae7
Source identifiers:
8673
Local pid:
pubs:8673
Language:
English

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