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Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable.

Abstract:

BACKGROUND: The developmental overnutrition hypothesis suggests that greater maternal obesity during pregnancy results in increased offspring adiposity in later life. If true, this would result in the obesity epidemic progressing across generations irrespective of environmental or genetic changes. It is therefore important to robustly test this hypothesis. METHODS AND FINDINGS: We explored this hypothesis by comparing the associations of maternal and paternal pre-pregnancy body mass index (BM...

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Journal:
PLoS medicine
Volume:
5
Issue:
3
Pages:
e33
Publication date:
2008-03-05
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:2552682c-535e-4ae8-a318-baa3ba415a17
Source identifiers:
93113
Local pid:
pubs:93113

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