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Thesis

Development and application of image analysis techniques to study structural and metabolic neurodegeneration in the human hippocampus using MRI and PET

Abstract:

Despite the association between hippocampal atrophy and a vast array of highly debilitating neurological diseases, such as Alzheimer’s disease and frontotemporal lobar degeneration, tools to accurately and robustly quantify the degeneration of this structure still largely elude us. In this thesis, we firstly evaluate previously-developed hippocampal segmentation methods (FMRIB’s Integrated Registration and Segmentation Tool (FIRST), Freesurfer (FS), and three versions of a Classifier Fusion (...

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Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Research group:
FMRIB Centre
Oxford college:
Merton College
Department:
Medical Sciences Division - Clinical Neurology
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:2549bad2-432f-4d0e-8878-be9cce6ae0d2
Local pid:
ora:6647

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