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Thesis

Development and application of image analysis techniques to study structural and metabolic neurodegeneration in the human hippocampus using MRI and PET

Abstract:

Despite the association between hippocampal atrophy and a vast array of highly debilitating neurological diseases, such as Alzheimer’s disease and frontotemporal lobar degeneration, tools to accurately and robustly quantify the degeneration of this structure still largely elude us. In this thesis, we firstly evaluate previously-developed hippocampal segmentation methods (FMRIB’s Integrated Registration and Segmentation Tool (FIRST), Freesurfer (FS), and three versions of a Classifier Fusion (...

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Institution:
University of Oxford
Research group:
FMRIB Centre
Oxford college:
Merton College
Role:
Author
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Division:
MSD
Department:
Clinical Neurosciences
Role:
Author

Contributors

Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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