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Journal article

A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting.

Abstract:

The triplet-based genetic code requires that translating ribosomes maintain the reading frame of a messenger RNA faithfully to ensure correct protein synthesis. However, in programmed -1 ribosomal frameshifting, a specific subversion of frame maintenance takes place, wherein the ribosome is forced to shift one nucleotide backwards into an overlapping reading frame and to translate an entirely new sequence of amino acids. This process is indispensable in the replication of numerous viral patho...

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Publication status:
Published

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Publisher copy:
10.1038/nature04735

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
Journal:
Nature
Volume:
441
Issue:
7090
Pages:
244-247
Publication date:
2006-05-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:25449e94-98bf-450e-aa74-477743440d38
Source identifiers:
14325
Local pid:
pubs:14325

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