Journal article

Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing

Abstract:: Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to mapping populations able to deliver gene-level mapping resolution, and the need for population specific genotyping arrays and haplotype reference panels. Here we combine low coverage sequencing (0.15X) with a novel method to impute the ancestral haplotype space in 1,887 commercially available outbred mice. We mapped 156 unique quantitative trait loci for 92 phenotypes at 5% false discovery rat...
Expand abstract
Collapse abstract

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Nicod, J., Davies, R., Cai, N., Hassett, C., Goodstadt, L., Cosgrove, C., Yee, B., Lionikaite, V., McIntyre, R., Remme, C., Lodder, E., Gregory, J., Hough, T., Joynson, R., Phelps, H., Nell, B., Rowe, C., Wood, J., Walling, A., … Flint, J. (2016). Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing. Nature Genetics, 48(8), 912–918.

MLA Style

Nicod, J., et al. “Genome-Wide Association of Multiple Complex Traits in Outbred Mice by Ultra-Low-Coverage Sequencing.” Nature Genetics, vol. 48, no. 8, Nature Publishing Group, 2016, pp. 912–18.

Chicago Style

Nicod, J, R Davies, N Cai, C Hassett, L Goodstadt, C Cosgrove, B Yee, et al. 2016. “Genome-Wide Association of Multiple Complex Traits in Outbred Mice by Ultra-Low-Coverage Sequencing.” Nature Genetics 48 (8): 912–18.
Tweet
Print

Access Document

Files:: Talbot et al, Genome-wide association of multiple complex trai...

(Preview, Accepted manuscript, pdf, 6.7MB, Terms of use)

Publisher copy:: 10.1038/ng.3595

Authors

+ Nicod, J More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Role:

Author

+ Davies, R More by this author

Role:

Author

+ Cai, N More by this author

Role:

Author

+ Hassett, C More by this author

Role:

Author

+ Goodstadt, L More by this author

Role:

Author

More authors...

Funding

+ Wellcome Trust More from this funder

Funding agency for:

Flint, J

Grant:

090532/Z/09/Z

+ InterUniversity Cardiology Institute of the Netherlands More from this funder

Grant:

061.02

+ Swiss National Science Foundation More from this funder

Grant:

SNF 136201

+ National Institutes of Health More from this funder

Grant:

R01AR056280

+ Medical Research Council More from this funder

Grant:

MC U142684172

More funders...

Bibliographic Details

Publisher:: Nature Publishing Group
Journal:: Nature Genetics More from this journal
Volume:: 48
Issue:: 8
Pages:: 912-918
Publication date:: 2016-07-01
Acceptance date:: 2016-05-24
DOI:: 10.1038/ng.3595
ISSN:: 1546-1718 and 1061-4036

Item Description

Language:: English
Keywords:: Journal Article
Pubs id:: pubs:632341
UUID:: uuid:2540937f-c549-44b4-8582-1d30266f1205
Local pid:: pubs:632341
Source identifiers:: 632341
Deposit date:: 2016-08-20

Terms of use

Copyright holder:: Macmillan Publishers Limited
Copyright date:: 2016
Notes:: © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Metrics

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP