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Journal article

Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing

Abstract:

Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to mapping populations able to deliver gene-level mapping resolution, and the need for population specific genotyping arrays and haplotype reference panels. Here we combine low coverage sequencing (0.15X) with a novel method to impute the ancestral haplotype space in 1,887 commercially available outbred mice. We mapped 156 unique quantitative trait loci for 92 phenotypes at 5% false discovery rat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ng.3595

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Funding agency for:
Flint, J
Grant:
090532/Z/09/Z
State of Vaud (Switzerland) More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
48
Issue:
8
Pages:
912-918
Publication date:
2016-07-01
Acceptance date:
2016-05-24
DOI:
ISSN:
1546-1718 and 1061-4036
Source identifiers:
632341
Language:
English
Keywords:
Pubs id:
pubs:632341
UUID:
uuid:2540937f-c549-44b4-8582-1d30266f1205
Local pid:
pubs:632341
Deposit date:
2016-08-20

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