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Journal article

Stable integration of large (>100 kb) PAC constructs in HaCaT keratinocytes using an integrin-targeting peptide delivery system.

Abstract:

Transfer of large DNA constructs in gene therapy studies is being recognised for its importance in maintaining the natural genomic environment of the gene of interest and providing tissue-specific regulation and control. However, methods used to deliver such constructs have been poorly studied. We used a receptor-mediated, integrin-targeting transfection system enhanced by liposomes, to deliver a 110 kb PAC (P1-based artificial chromosome) to HaCaT keratinocytes. The PAC contained the collage...

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Publication status:
Published

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Publisher copy:
10.1038/sj.gt.3301280

Authors


Compton, SH More by this author
Mecklenbeck, S More by this author
Mejía, JE More by this author
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Journal:
Gene therapy
Volume:
7
Issue:
18
Pages:
1600-1605
Publication date:
2000-09-05
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
URN:
uuid:253880a4-456a-4c9d-9606-d7bf18dbf2a0
Source identifiers:
53443
Local pid:
pubs:53443

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