Journal article
Rational development of a protective P. vivax vaccine evaluated with transgenic rodent parasite challenge models
- Abstract:
-
Development of a protective and broadly-acting vaccine against the most widely distributed human malaria parasite, Plasmodium vivax, will be a major step towards malaria elimination. However, a P. vivax vaccine has remained elusive by the scarcity of pre-clinical models to test protective efficacy and support further clinical trials. In this study, we report the development of a highly protective CSP-based P. vivax vaccine, a virus-like particle (VLP) known as Rv21, able to provide 100% steri...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Medical Research Council
More from this funder
Funding agency for:
Reyes-Sandoval, A
Grant:
MR/N019008/1
+ Wellcome Trust
More from this funder
Funding agency for:
Hill, A
Reyes-Sandoval, A
Grant:
095540/Z/11/Z
MR/N019008/1
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 7
- Issue:
- 46482
- Pages:
- 1-19
- Publication date:
- 2017-04-18
- Acceptance date:
- 2017-03-15
- DOI:
- ISSN:
-
2045-2322
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:690767
- UUID:
-
uuid:253088ab-439a-43fe-82a6-56f80cdb1876
- Local pid:
- pubs:690767
- Deposit date:
- 2017-04-24
Terms of use
- Copyright holder:
- © Salman, et al
- Copyright date:
- 2017
- Notes:
- This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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