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Rapid activation of spleen dendritic cell subsets following lymphocytic choriomeningitis virus infection of mice: analysis of the involvement of type 1 IFN.

Abstract:

In this study, we report the dynamic changes in activation and functions that occur in spleen dendritic cell (sDC) subsets following infection of mice with a natural murine pathogen, lymphocytic choriomeningitis virus (LCMV). Within 24 h postinfection (pi), sDCs acquired the ability to stimulate naive LCMV-specific CD8+ T cells ex vivo. Conventional (CD11chigh CD8+ and CD4+) sDC subsets rapidly up-regulated expression of costimulatory molecules and began to produce proinflammatory cytokines. ...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.174.4.1851

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
174
Issue:
4
Pages:
1851-1861
Publication date:
2005-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:252b241d-f91c-47a8-ba59-b1febc5ac361
Source identifiers:
32986
Local pid:
pubs:32986

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