Journal article icon

Journal article

Comparing the fine specificity of DNA binding by NF-kappaB p50 and p52 using principal coordinates analysis.

Abstract:

Principal coordinates analysis has been proposed as an efficient way of predicting the binding affinity of a transcription factor to different DNA motifs, as it can model complex interactions that are difficult to represent with standard position-weight matrices. Here we evaluate its ability to distinguish the DNA binding properties of two closely related proteins, the homodimeric forms of NF-kappaB p50 and p52. When tested experimentally against 50 different variants of the generalised NF-ka...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/nar/gkg231

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Udalova, IA More by this author
Journal:
Nucleic acids research
Volume:
31
Issue:
5
Pages:
1497-1501
Publication date:
2003-03-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:252a6ec3-ae7f-4805-b91b-fba0ca2faa19
Source identifiers:
32314
Local pid:
pubs:32314

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP