Advanced Radiotherapy Technologies in Spine Tumors: What the Surgeon Needs to Know

Chen, H; Ghia, AJ; Maralani, PJ; Bettegowda, C; Boriani, S; Dea, N; Fisher, CG; Gasbarrini, A; Gokaslan, ZL; Laufer, I; Lazary, A; Reynolds, J; Verlaan, J; Rhines, LD; Sahgal, A

Journal article

Advanced Radiotherapy Technologies in Spine Tumors: What the Surgeon Needs to Know

Abstract:: Study designNarrative review of existing literature.ObjectivesSignificant technological advancements in radiotherapy planning and delivery have enabled new radiotherapy techniques for the management of spine tumors. The objective of this study was to provide a comprehensive summary of these treatment techniques for practicing spine surgeons.MethodsA narrative review of the existing literature on stereotactic body radiation therapy (SBRT) and particle beam therapy (PBT) for the treatment of spine tumors was performed. The characteristics, implementation and evidence supporting these strategies in the management of primary spinal neoplasms were summarized.ResultsThe clinical effectiveness of SBRT for the control and symptom palliation of metastatic spinal tumors are well demonstrated in multiple clinical trials. Risks such as fracture, radiculopathy and plexopathy exist after spine SBRT, necessitating an individualized approach in a well experienced multidisciplinary setting. SBRT should be considered a key component of a well-rounded treatment plan for metastatic spine tumors in combination with surgery, vertebral augmentation, and drug therapy, where indicated, to achieve optimal patient outcomes. Additionally, PBT and SBRT are also leading to promising results for primary spine tumors, though comparative effectiveness studies and prospective clinical trials are required to establish these modalities more formally as alternatives to conventionally fractionated photon radiotherapy.ConclusionsSBRT and PBT are emerging as effective and well tolerated treatment options for primary and metastatic spine tumors. Additional investigation is needed to personalize these treatment options and further strengthen these approaches as key components in a multidisciplinary approach to the management of spinal neoplasms.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Chen, H., Ghia, A. J., Maralani, P. J., Bettegowda, C., Boriani, S., Dea, N., Fisher, C. G., Gasbarrini, A., Gokaslan, Z. L., Laufer, I., Lazary, A., Reynolds, J., Verlaan, J., Rhines, L. D., & Sahgal, A. (2025). Advanced Radiotherapy Technologies in Spine Tumors: What the Surgeon Needs to Know. Global Spine Journal, 15(1_suppl), 104S–119S.

MLA Style

Chen, H., et al. “Advanced Radiotherapy Technologies in Spine Tumors: What the Surgeon Needs to Know.” Global Spine Journal, vol. 15, no. 1_suppl, SAGE Publications, 2025, pp. 104S–119S.

Chicago Style

Chen, H, AJ Ghia, PJ Maralani, C Bettegowda, S Boriani, N Dea, CG Fisher, et al. 2025. “Advanced Radiotherapy Technologies in Spine Tumors: What the Surgeon Needs to Know.” Global Spine Journal 15 (1_suppl): 104S–119S.
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