Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling.

Journal article

The regulation of stem cell ontogeny is poorly understood. We show that the leukemia-associated Ets transcription factor, Tel1/ETV6, specifies the first hematopoietic stem cells (HSCs) in the dorsal aorta (DA). In contrast, Tel1/ETV6 has little effect on embryonic blood formation, further distinguishing the programming of the long- and short-term blood populations. Consistent with the notion of concordance of arterial and HSC programs, we show that Tel1/ETV6 is also required for the specifica...

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Authors: Ciau-Uitz, A; Pinheiro, P; Gupta, R; Enver, T; Patient, R

• Publication status: Published
• Journal: Developmental cell
• Volume: 18
• Issue: 4
• Pages: 569-578
• Publication date: 2010-04-01
• DOI: 10.1016/j.devcel.2010.02.009
• EISSN: 1878-1551
• ISSN: 1534-5807
• Language: English
• Keywords: Models, Biological; Humans; Models, Genetic; Phenotype; Transcription, Genetic; Signal Transduction; Hematopoietic Stem Cells; Vascular Endothelial Growth Factor A; Molecular Sequence Data; Repressor Proteins; Hemangioblasts; Proto-Oncogene Proteins c-ets; In Situ Hybridization; Gene Expression Regulation, Developmental; Mesoderm; Blood Cells; Somites