Journal article icon

Journal article

Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores.

Abstract:

INTRODUCTION: Osteoarthritis trials usually report average changes in visual analogue scale (VAS) pain, and examine the difference between treatment and placebo. We investigated whether dichotomous responder analysis provides a more informative interpretation of drug efficacy. METHODS: Merck supplied the number of patients who, by 6 weeks, had achieved pain relief compared with a baseline of 0% or more, 10% or more, 20% or more, and so on at equal intervals up to 90% or more. These different...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1186/ar2394

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
McQuay, HJ More by this author
Journal:
Arthritis research and therapy
Volume:
10
Issue:
2
Pages:
R39
Publication date:
2008
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
URN:
uuid:25199bda-cc18-435f-91ef-bb61218e31db
Source identifiers:
241579
Local pid:
pubs:241579

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP