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Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells.

Abstract:

We have explored whether gamma-aminobutyric acid (GABA) is released by regulated exocytosis of GABA-containing synaptic-like microvesicles (SLMVs) in insulin-releasing rat pancreatic beta-cells. To this end, beta-cells were engineered to express GABA(A)-receptor Cl(-)-channels at high density using adenoviral infection. Electron microscopy indicated that the average diameter of the SLMVs is 90 nm, that every beta-cell contains approximately 3,500 such vesicles, and that insulin-containing lar...

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Publication status:
Published

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Publisher copy:
10.1085/jgp.200308966

Authors


Eliasson, L More by this author
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Journal:
The Journal of general physiology
Volume:
123
Issue:
3
Pages:
191-204
Publication date:
2004-03-05
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
URN:
uuid:2516aa10-3f15-415d-a89d-24069b4e8652
Source identifiers:
18114
Local pid:
pubs:18114

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