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Association between NICE guidance on biologic therapies with rates of hip and knee replacement among rheumatoid arthritis patients in England and Wales: an interrupted time-series analysis

Abstract:

Objective: To estimate the impact of NICE approval of tumour necrosis factor inhibitor (TNFi) therapies on the incidence of total hip replacement (THR) and total knee replacement (TKR) among rheumatoid arthritis (RA) patients in England and Wales.

Methods: Primary care data (Clinical Practice Research Datalink (CPRD)) for the study period (1995-2014) were used to identify incident adult RA patients. The age and sex-standardised 5-year incidence of THR and TKR was calculated separatel...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.semarthrit.2017.09.006

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Funding agency for:
Dreyer, L
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Funding agency for:
Dreyer, L
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Funding agency for:
Edwards, C
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Publisher:
Elsevier Publisher's website
Journal:
Seminars in Arthritis and Rheumatism Journal website
Volume:
47
Issue:
5
Pages:
605-610
Publication date:
2017-09-23
Acceptance date:
2017-09-20
DOI:
ISSN:
0049-0172 and 1532-866X
Source identifiers:
730775
Pubs id:
pubs:730775
UUID:
uuid:25122079-e8f4-476f-8e8f-50890869b241
Local pid:
pubs:730775
Deposit date:
2017-09-27

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