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Lysyl oxidase‐like 2 is a regulator of angiogenesis through modulation of endothelial‐to‐mesenchymal transition

Abstract:

Lysyl oxidase‐like 2 (LOXL2) belongs to the family of lysyl oxidases, and as such promotes crosslinking of collagens and elastin by oxidative deamination of lysine residues. In endothelial cells (ECs), LOXL2 is involved in crosslinking and scaffolding of collagen IV. Additionally, several reports have shown a role for LOXL2 in other processes, including regulation of gene expression, tumor metastasis, and epithelial‐to‐mesenchymal transition (EMT). Here, we demonstrate an additional role for ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1002/jcp.27695

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Van Der Waals, LM More by this author
Kools, FRW More by this author
Verhaar, MC More by this author
Van Balkom, BWM More by this author
Publisher:
Wiley Publisher's website
Journal:
Journal of Cellular Physiology Journal website
Volume:
234
Issue:
7
Pages:
10260-10269
Publication date:
2018-11-01
Acceptance date:
2018-10-09
DOI:
EISSN:
1097-4652
ISSN:
0021-9541
Pubs id:
pubs:938357
URN:
uri:2508b983-0cbc-4053-a896-6820255d455c
UUID:
uuid:2508b983-0cbc-4053-a896-6820255d455c
Local pid:
pubs:938357

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