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Lack of dendritic cell maturation by the plant toxin ricin.

Abstract:

Several bacterial toxins either promote or inhibit the maturation of human monocyte-derived DC. Since the potent plant toxin ricin exploits the same cell entry pathway used by these bacterial toxins and shares identical catalytic activity with some of them, we have studied the capacity of ricin to induce DC maturation in vitro. Here, we show that in contrast to the bacterial proteins, ricin neither induces DC maturation nor interferes with LPS-induced DC maturation. There is no correlation be...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200425157

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Role:
Author
Journal:
European journal of immunology
Volume:
34
Issue:
8
Pages:
2149-2157
Publication date:
2004-08-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:25028de4-b959-464a-b6ee-ff8795ee8499
Source identifiers:
32782
Local pid:
pubs:32782

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