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Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations.

Abstract:

Sialoadhesin is a macrophage-restricted cellular interaction molecule and a prototypic member of the Siglec family of sialic acid binding immunoglobulin (Ig)-like lectins. So far, it has only been characterized in rodents. Here, we report the molecular cloning, binding properties, and expression pattern of human sialoadhesin. The predicted protein sequences of human and mouse sialoadhesin are about 72% identical, with the greatest similarity in the extracellular region, which comprises 17 Ig ...

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Publication status:
Published

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Publisher copy:
10.1182/blood.v97.1.288

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Journal:
Blood More from this journal
Volume:
97
Issue:
1
Pages:
288-296
Publication date:
2001-01-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971

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