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Journal article

Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated embryonic stem cells.

Abstract:

BACKGROUND: Expression of Xist, the master regulator of X chromosome inactivation, is extinguished in pluripotent cells, a process that has been linked to programmed X chromosome reactivation. The key pluripotency transcription factors Nanog, Oct4 and Sox2 are implicated in Xist gene extinction, at least in part through binding to an element located in Xist intron 1. Other pathways, notably repression by the antisense RNA Tsix, may also be involved. RESULTS: Here we employ a transgene strateg...

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Publication status:
Published

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Publisher copy:
10.1186/1756-8935-4-17

Authors


Nesterova, TB More by this author
Senner, CE More by this author
Schneider, J More by this author
Alcayna-Stevens, T More by this author
Tattermusch, A More by this author
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Journal:
Epigenetics and chromatin
Volume:
4
Issue:
1
Pages:
17
Publication date:
2011
DOI:
EISSN:
1756-8935
ISSN:
1756-8935
URN:
uuid:24e8847b-75ec-49ec-8dbb-d3f5598bc999
Source identifiers:
186659
Local pid:
pubs:186659
Language:
English

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