- Abstract:
-
BACKGROUND: Expression of Xist, the master regulator of X chromosome inactivation, is extinguished in pluripotent cells, a process that has been linked to programmed X chromosome reactivation. The key pluripotency transcription factors Nanog, Oct4 and Sox2 are implicated in Xist gene extinction, at least in part through binding to an element located in Xist intron 1. Other pathways, notably repression by the antisense RNA Tsix, may also be involved. RESULTS: Here we employ a transgene strateg...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1186/1756-8935-4-17
-
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- Journal:
- Epigenetics and chromatin
- Volume:
- 4
- Issue:
- 1
- Pages:
- 17
- Publication date:
- 2011
- DOI:
- EISSN:
-
1756-8935
- ISSN:
-
1756-8935
- URN:
-
uuid:24e8847b-75ec-49ec-8dbb-d3f5598bc999
- Source identifiers:
-
186659
- Local pid:
- pubs:186659
- Language:
- English
- Copyright date:
- 2011
Journal article
Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated embryonic stem cells.
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