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Teneurin structures are composed of ancient bacterial protein domains

Abstract:

Pioneering bioinformatic analysis using sequence data revealed that teneurins evolved from bacterial tyrosine-aspartate (YD)-repeat protein precursors. Here, we discuss how structures of the C-terminal domain of teneurins, determined using X-ray crystallography and electron microscopy, support the earlier findings on the proteins' ancestry. This chapter describes the structure of the teneurin scaffold with reference to a large family of teneurin-like proteins that are widespread in modern pro...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
St Anne's College
Role:
Author
ORCID:
0000-0001-6112-5198
More from this funder
Name:
European Research Council
Grant:
677500
More from this funder
Name:
Wellcome Trust
Grant:
202827/Z/16/Z
Publisher:
Frontiers Media
Journal:
Frontiers in Neuroscience More from this journal
Volume:
13
Article number:
183
Publication date:
2019-03-13
Acceptance date:
2019-02-15
DOI:
EISSN:
1662-453X
ISSN:
1662-4548
Pmid:
30930731
Language:
English
Keywords:
Pubs id:
pubs:986958
UUID:
uuid:24e0e24c-3277-4dbf-bb50-4a2192806c97
Local pid:
pubs:986958
Source identifiers:
986958
Deposit date:
2019-06-14

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