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The half-life of exogenous growth hormone after suppression of endogenous growth hormone secretion with somatostatin.

Abstract:

We have estimated the half-life of serum growth hormone (GH) in six subjects on 14 occasions following an intravenous bolus injection of either 50 or 500 mU of biosynthetic human growth hormone (B-hGH) while endogenous GH secretion was suppressed by a continuous infusion of somatostatin. The disappearance curve of serum GH was mono-exponential and the mean half-life was 8.9 min (SD 1.5). This is less than previously reported and has important implications for the performance of GH profiles, w...

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Publication status:
Published

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Journal:
Clinical endocrinology More from this journal
Volume:
30
Issue:
4
Pages:
443-450
Publication date:
1989-04-01
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
Language:
English
Keywords:
Pubs id:
pubs:72979
UUID:
uuid:24d99c64-61c0-43c4-aa70-b3752ab3da5a
Local pid:
pubs:72979
Source identifiers:
72979
Deposit date:
2012-12-19

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