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Type 1 insulin-like growth factor signalling in malignant melanoma

Abstract:

Novel therapeutic strategies are sorely required for malignant melanoma, which has been shown to overexpress the type 1 insulin-like growth factor receptor (IGF1R) compared to benign naevi. The IGF1R mediates many features of the malignant phenotype and is an attractive anti-cancer therapeutic target. Inoculation with IGF1R depleted tumour cells has been shown to upregulate MHC Class 1 expression and confer protection from tumour rechallenge in vivo. The initial aim of this project was to ...

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Institution:
University of Oxford
Department:
Medical Sciences Division - Medical Oncology

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Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Language:
English
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