- Abstract:
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Novel therapeutic strategies are sorely required for malignant melanoma, which has been shown to overexpress the type 1 insulin-like growth factor receptor (IGF1R) compared to benign naevi. The IGF1R mediates many features of the malignant phenotype and is an attractive anti-cancer therapeutic target. Inoculation with IGF1R depleted tumour cells has been shown to upregulate MHC Class 1 expression and confer protection from tumour rechallenge in vivo. The initial aim of this project was to ...
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- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Mark Robert Goodfellow
- Copyright date:
- 2013
Thesis
Type 1 insulin-like growth factor signalling in malignant melanoma
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