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Imaging endogenous opioid peptide release with [11C]carfentanil and [3H]diprenorphine: influence of agonist-induced internalization

Abstract:

Understanding the cellular processes underpinning the changes in binding observed during positron emission tomography neurotransmitter release studies may aid translation of these methodologies to other neurotransmitter systems. We compared the sensitivities of opioid receptor radioligands, carfentanil, and diprenorphine, to amphetamine-induced endogenous opioid peptide (EOP) release and methadone administration in the rat. We also investigated whether agonist-induced internalization was invo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/jcbfm.2014.117

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
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Name:
Medical Research Council
Grant:
G1002226
G0400575
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Publisher:
SAGE Publications
Journal:
Journal of Cerebral Blood Flow and Metabolism More from this journal
Volume:
34
Issue:
10
Pages:
1604-1612
Publication date:
2014-07-09
Acceptance date:
2014-06-11
DOI:
EISSN:
1559-7016
ISSN:
0271-678X
Pmid:
25005876
Language:
English
Keywords:
Pubs id:
pubs:614439
UUID:
uuid:24d1c1ac-6be3-423f-8c57-9bbf0d35e3df
Local pid:
pubs:614439
Source identifiers:
614439
Deposit date:
2016-09-13

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