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T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal?

Abstract:

Dengue virus infection poses a growing public health and economic burden in a number of tropical and subtropical countries. Dengue circulates as a number of quasispecies, which can be divided by serology into four groups or serotypes. An interesting feature of Dengue, recognized over five decades ago, is that most severe cases that show hemorrhagic fever are not suffering from a primary infection. Instead, they are reinfected with a virus of different serotype. This observation poses consider...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.176.6.3821

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Journal:
Journal of Immunology
Volume:
176
Issue:
6
Pages:
3821-3829
Publication date:
2006-03-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
95806
Language:
English
Keywords:
Pubs id:
pubs:95806
UUID:
uuid:24d0e6bb-6581-493b-9543-31fd3c69bf19
Local pid:
pubs:95806
Deposit date:
2013-11-16

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