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Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

Abstract:

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium falciparum malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, K13-propeller genotyping confirms the emergence of the R561H mutation in Rwanda and highlights the continuing dominance of wild-type K13 elsewhere. Using gene editing, we show that R561H, along with C580Y and M579I, confer elevated in vitro ART resistance in some African strains, contrasting with minimal changes...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.66277

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Role:
Author
ORCID:
0000-0001-9519-487X
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Role:
Author
ORCID:
0000-0002-4149-4030
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Role:
Author
ORCID:
0000-0002-9605-0154
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Name:
National Institutes of Health
Funder identifier:
http://dx.doi.org/10.13039/100000002
Publisher:
eLife Sciences Publications
Journal:
eLife More from this journal
Volume:
10
Article number:
e66277
Place of publication:
England
Publication date:
2021-07-19
Acceptance date:
2021-07-17
DOI:
EISSN:
2050-084X
Pmid:
34279219
Language:
English
Keywords:
Pubs id:
1187631
Local pid:
pubs:1187631
Deposit date:
2021-12-22

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