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Statistical analysis of scanning fluorescence correlation spectroscopy data differentiates free from hindered diffusion

Abstract:

Cells rely on versatile diffusion dynamics in their plasma membrane. Quantification of this often heterogeneous diffusion is essential to the understanding of cell regulation and function. Yet such measurements remain a major challenge in cell biology, usually due to low sampling throughput, a necessity for dedicated equipment, sophisticated fluorescent label strategies, and limited sensitivity. Here, we introduce a robust, broadly-applicable statistical analysis pipeline for large scanning-f...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acsnano.8b04080

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM - Investigative Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM - Investigative Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM - Investigative Medicine Division
Role:
Author
ORCID:
0000-0002-4915-388X
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Wolfson Foundation More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
ACS Nano Journal website
Volume:
12
Issue:
8
Pages:
8540–8546
Publication date:
2018-07-20
Acceptance date:
2018-07-20
DOI:
EISSN:
1936-086X
ISSN:
1936-0851
Pmid:
30028588
Language:
English
Keywords:
Pubs id:
pubs:891324
UUID:
uuid:24c95c31-98a5-4d9d-8f3f-f5649c37a976
Local pid:
pubs:891324
Deposit date:
2018-08-02

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