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A Nonsense Mutation in TLR5 Is Associated with Survival and Reduced IL-10 and TNF-α Levels in Human Melioidosis

Abstract:

Background
Melioidosis, caused by the flagellated bacterium Burkholderia pseudomallei, is a life-threatening and increasingly recognized emerging disease. Toll-like receptor (TLR) 5 is a germline-encoded pattern recognition receptor to bacterial flagellin. We evaluated the association of a nonsense TLR5 genetic variant that truncates the receptor with clinical outcomes and with immune responses in melioidosis.

Methodology/Principle Findings
We genotyped TLR5 c.1174C>T ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pntd.0005587

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Neglected Tropical Diseases Journal website
Volume:
11
Issue:
5
Pages:
e0005587
Publication date:
2017-05-05
Acceptance date:
2017-04-28
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Pubs id:
pubs:692087
URN:
uri:24c7d1cb-2842-42e6-b645-ce5764b52ff4
UUID:
uuid:24c7d1cb-2842-42e6-b645-ce5764b52ff4
Local pid:
pubs:692087
Paper number:
5

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