- Abstract:
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Background
Expand abstract
Melioidosis, caused by the flagellated bacterium Burkholderia pseudomallei, is a life-threatening and increasingly recognized emerging disease. Toll-like receptor (TLR) 5 is a germline-encoded pattern recognition receptor to bacterial flagellin. We evaluated the association of a nonsense TLR5 genetic variant that truncates the receptor with clinical outcomes and with immune responses in melioidosis.
Methodology/Principle Findings
We genotyped TLR5 c.1174C>T ... - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 1.1MB)
-
- Publisher copy:
- 10.1371/journal.pntd.0005587
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Neglected Tropical Diseases Journal website
- Volume:
- 11
- Issue:
- 5
- Pages:
- e0005587
- Publication date:
- 2017-05-05
- Acceptance date:
- 2017-04-28
- DOI:
- EISSN:
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1935-2735
- ISSN:
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1935-2727
- Pubs id:
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pubs:692087
- URN:
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uri:24c7d1cb-2842-42e6-b645-ce5764b52ff4
- UUID:
-
uuid:24c7d1cb-2842-42e6-b645-ce5764b52ff4
- Local pid:
- pubs:692087
- Paper number:
- 5
- Copyright holder:
- Chaichana et al.
- Copyright date:
- 2017
- Notes:
- © 2017 Chaichana et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
Journal article
A Nonsense Mutation in TLR5 Is Associated with Survival and Reduced IL-10 and TNF-α Levels in Human Melioidosis
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