Melioidosis, caused by the flagellated bacterium Burkholderia pseudomallei, is a life-threatening and increasingly recognized emerging disease. Toll-like receptor (TLR) 5 is a germline-encoded pattern recognition receptor to bacterial flagellin. We evaluated the association of a nonsense TLR5 genetic variant that truncates the receptor with clinical outcomes and with immune responses in melioidosis.
We genotyped TLR5 c.1174C>T ...
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- Public Library of Science Publisher's website
- PLoS Neglected Tropical Diseases Journal website
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- Chaichana et al.
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- © 2017 Chaichana et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
A Nonsense Mutation in TLR5 Is Associated with Survival and Reduced IL-10 and TNF-α Levels in Human Melioidosis
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