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Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia.

Abstract:

OBJECTIVE: Tryptophan degradation and depletion resulting from activation of indoleamine 2,3-dioxygenase is characteristic of inflammatory reactions and may control their intensity. Normal third-trimester pregnancy is characterized by a maternal systemic inflammatory response, which is more intense in preeclampsia. Therefore, we studied tryptophan metabolism in pregnant women, with or without preeclampsia, as well as expression and function of placental indoleamine 2,3-dioxygenase. STUDY DES...

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Publication status:
Published

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Publisher copy:
10.1067/mob.2003.156

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Journal:
American journal of obstetrics and gynecology
Volume:
188
Issue:
3
Pages:
719-726
Publication date:
2003-03-05
DOI:
EISSN:
1097-6868
ISSN:
0002-9378
URN:
uuid:24c644fb-dd94-40b0-843f-2d0d4dcb2e68
Source identifiers:
113993
Local pid:
pubs:113993

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