Journal article
Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate.
- Abstract:
-
Macrophages and myeloid dendritic cells (DCs) represent alternative differentiation options of bone marrow progenitors and blood monocytes. This choice profoundly influences the immune response under normal and pathological conditions, but the underlying transcriptional events remain unresolved. Here, we show that experimental activation of the transcription factors PU.1 and MafB in transformed chicken myeloid progenitors triggered alternative DC or macrophage fate, respectively. PU.1 activat...
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- Publisher copy:
- 10.1182/blood-2004-04-1448
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Authors
Bibliographic Details
- Journal:
- Blood
- Volume:
- 105
- Issue:
- 7
- Pages:
- 2707-2716
- Publication date:
- 2005-04-01
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- Source identifiers:
-
324045
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:324045
- UUID:
-
uuid:24b70add-c12e-4e8f-bb50-fd1775f9b4aa
- Local pid:
- pubs:324045
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2005
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