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Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate.

Abstract:

Macrophages and myeloid dendritic cells (DCs) represent alternative differentiation options of bone marrow progenitors and blood monocytes. This choice profoundly influences the immune response under normal and pathological conditions, but the underlying transcriptional events remain unresolved. Here, we show that experimental activation of the transcription factors PU.1 and MafB in transformed chicken myeloid progenitors triggered alternative DC or macrophage fate, respectively. PU.1 activat...

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Publisher copy:
10.1182/blood-2004-04-1448

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Lab Sciences
Role:
Author
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Journal:
Blood
Volume:
105
Issue:
7
Pages:
2707-2716
Publication date:
2005-04-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
324045

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