Journal article
IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer
- Abstract:
-
Background: Activated type 1 IGF receptors (IGF-1Rs) undergo internalisation and nuclear translocation, promoting cell survival. We reported that IGF-1R inhibition delays DNA damage repair, sensitising prostate cancer cells to ionising radiation. Here, we tested the clinical relevance of these findings.
Methods: We assessed associations between IGF-1R and clinical outcomes by immunohistochemistry in diagnostic biopsies of 136 men treated with 55-70 Gy external beam radiotherapy for ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ National Institute for Health Research
More from this funder
Funding agency for:
Macaulay, V
Grant:
AC14/037
Bibliographic Details
- Publisher:
- Cancer Research UK Publisher's website
- Journal:
- British Journal of Cancer Journal website
- Volume:
- 117
- Issue:
- 2017
- Pages:
- 1600-1606
- Publication date:
- 2017-10-03
- Acceptance date:
- 2017-08-06
- DOI:
- EISSN:
-
1532-1827
- ISSN:
-
0007-0920
Item Description
- Pubs id:
-
pubs:724711
- UUID:
-
uuid:24b3d799-dd13-4208-8bfc-76458a687e09
- Local pid:
- pubs:724711
- Source identifiers:
-
724711
- Deposit date:
- 2017-08-31
Terms of use
- Copyright holder:
- © 2017 Cancer Research UK All righst reserved
- Copyright date:
- 2017
- Notes:
- This is the publisher's version of the article. The final version is available online from Cancer Research UK at: 10.1038/bjc.2017.337
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