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Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease.

Abstract:

Graft-versus-host disease (GvHD) is a chief complication of allogeneic bone marrow transplantation. In HLA-identical bone marrow transplantation, GvHD may be induced by disparities in minor histocompatibility antigens (mHags) between the donor and the recipient, with the antigen being present in the recipient and not in the donor. Cytotoxic T lymphocytes (CTLs) specific for mHags of the recipients can be isolated from the blood of recipients with severe GvHD (ref. 3). A retrospective study de...

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Publisher copy:
10.1038/10563

Authors


Journal:
Nature medicine More from this journal
Volume:
5
Issue:
7
Pages:
839-842
Publication date:
1999-07-01
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Language:
English
Keywords:
Pubs id:
pubs:95852
UUID:
uuid:24acff6d-8469-4bc1-b1c0-cb8d72080e3a
Local pid:
pubs:95852
Source identifiers:
95852
Deposit date:
2013-02-20

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