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VEGF, FLT3 ligand, PlGF and HGF can substitute for M-CSF to induce human osteoclast formation: implications for giant cell tumour pathobiology.

Abstract:

Giant cell tumour of bone (GCTB) is a primary bone tumour that contains numerous very large, hyper-nucleated osteoclastic giant cells. Osteoclasts form from CD14+ monocytes and macrophages in the presence of receptor activator of nuclear factor kappa B ligand (RANKL) and macrophage-colony stimulating factor (M-CSF). GCTB contains numerous growth factors, some of which have been reported to influence osteoclastogenesis and resorption. We investigated whether these growth factors are capable of...

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Publication status:
Published

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Publisher copy:
10.1038/labinvest.2012.108

Authors


Taylor, RM More by this author
Kashima, TG More by this author
Knowles, HJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Laboratory investigation; a journal of technical methods and pathology
Volume:
92
Issue:
10
Pages:
1398-1406
Publication date:
2012-10-05
DOI:
EISSN:
1530-0307
ISSN:
0023-6837
URN:
uuid:24a986f4-1c07-4621-b5b7-89f93098f423
Source identifiers:
349830
Local pid:
pubs:349830

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