- Abstract:
-
In a phase II/III clinical trial intraperitoneal (i.p.) administration of a group C adenovirus vector (Ad5) caused bowel adhesion formation, perforation and obstruction. However, we had found that i.p. group B, in contrast to group C adenoviruses, did not cause adhesions in nude BALB/c ovarian cancer models, prompting further investigation. Ex vivo, group B Ad11 caused lower inflammatory responses than Ad5 on BALB/c peritoneal macrophages. In vivo, i.p. Ad11 triggered short-term cytokine and ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.virol.2013.08.032
-
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- Journal:
- Virology
- Volume:
- 447
- Issue:
- 1-2
- Pages:
- 74-83
- Publication date:
- 2013-12-05
- DOI:
- EISSN:
-
1096-0341
- ISSN:
-
0042-6822
- URN:
-
uuid:24a06f30-20c7-414b-b2fa-cf3c301699ef
- Source identifiers:
-
432166
- Local pid:
- pubs:432166
- Copyright date:
- 2013
Journal article
Adenovirus serotype 11 causes less long-term intraperitoneal inflammation than serotype 5: implications for ovarian cancer therapy.
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