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Adenovirus serotype 11 causes less long-term intraperitoneal inflammation than serotype 5: implications for ovarian cancer therapy.

Abstract:

In a phase II/III clinical trial intraperitoneal (i.p.) administration of a group C adenovirus vector (Ad5) caused bowel adhesion formation, perforation and obstruction. However, we had found that i.p. group B, in contrast to group C adenoviruses, did not cause adhesions in nude BALB/c ovarian cancer models, prompting further investigation. Ex vivo, group B Ad11 caused lower inflammatory responses than Ad5 on BALB/c peritoneal macrophages. In vivo, i.p. Ad11 triggered short-term cytokine and ...

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Publication status:
Published

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Publisher copy:
10.1016/j.virol.2013.08.032

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
Role:
Author
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Journal:
Virology
Volume:
447
Issue:
1-2
Pages:
74-83
Publication date:
2013-12-05
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
URN:
uuid:24a06f30-20c7-414b-b2fa-cf3c301699ef
Source identifiers:
432166
Local pid:
pubs:432166

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