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Journal article

A mechanosensitive cation channel in endothelial cells and its role in vasoregulation.

Abstract:

Ca2+ is an important intracellular second messenger in signal transduction of endothelial cells. It has long been recognized that a mechanosensitive Ca2+-permeable channel is present in vascular endothelial cells. The activity of this channel may increase intracellular Ca2+ level in endothelial cells. A recent finding is that the activity of this channel may be regulated by cGMP through a protein kinase G-dependent pathway. Inhibition of the channel by cGMP abolishes the Ca2+ influx elicited ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Biorheology More from this journal
Volume:
40
Issue:
1-3
Pages:
23-30
Publication date:
2003-01-01
EISSN:
1878-5034
ISSN:
0006-355X
Language:
English
Keywords:
Pubs id:
pubs:106478
UUID:
uuid:249bbcc9-3c0f-49eb-ad9d-237b769703bf
Local pid:
pubs:106478
Source identifiers:
106478
Deposit date:
2012-12-19

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