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Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.

Abstract:

Amyloid β (Aβ) and tau protein are both implicated in memory impairment, mild cognitive impairment (MCI), and early Alzheimer's disease (AD), but whether and how they interact is unknown. Consequently, we asked whether tau protein is required for the robust phenomenon of Aβ-induced impairment of hippocampal long-term potentiation (LTP), a widely accepted cellular model of memory. We used wild-type mice and mice with a genetic knock-out of tau protein and recorded field potentials in an acute ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
31
Issue:
5
Pages:
1688-1692
Publication date:
2011-02-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:249815df-d056-4e57-9d04-a61b3e83e17a
Source identifiers:
115781
Local pid:
pubs:115781

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