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Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation.

Abstract:

Recent experimental evidence points to intermediates populated during the process of amyloid fibril formation as the toxic moieties primarily responsible for the development of increasingly common disorders such as Alzheimer's disease and type II diabetes. We describe here the application of a pulse-labeling hydrogen-deuterium (HD) exchange strategy monitored by mass spectrometry (MS) and NMR spectroscopy (NMR) to characterize the aggregation process of an SH3 domain under 2 different conditi...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0812227106

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
106
Issue:
19
Pages:
7828-7833
Publication date:
2009-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:24971bba-b5b4-4245-be2c-ec2277a0fa0c
Source identifiers:
59402
Local pid:
pubs:59402

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