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Skin allograft rejection by L3/T4+ and Lyt-2+ T cell subsets.

Abstract:

The L3/T4+ and Lyt-2+ T-cell subsets can be depleted from mice, using selected monoclonal antibodies in vivo, at different times during rejection of, or priming to, allogeneic skin grafts. Although L3/T4+ cells are sufficient to reject skin grafts in naive Lyt-2-depleted mice, we show that Lyt-2+ cells can become involved, after an initial delay, in intact mice. Furthermore, these Lyt-2+ cells are primed to dominate the accelerated rejection of a normal secondary response. Mice depleted of L3...

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Publication status:
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Authors


Cobbold, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Transplantation
Volume:
41
Issue:
5
Pages:
634-639
Publication date:
1986-05-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:2496e0ee-da60-441b-ade3-3b32937e189a
Source identifiers:
11424
Local pid:
pubs:11424

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