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Tetrameric assembly of KvLm K+ channels with defined numbers of voltage sensors.

Abstract:

Voltage-gated K(+) (Kv) channels are tetrameric assemblies in which each modular subunit consists of a voltage sensor and a pore domain. KvLm, the voltage-gated K(+) channel from Listeria monocytogenes, differs from other Kv channels in that its voltage sensor contains only three out of the eight charged residues previously implicated in voltage gating. Here, we ask how many sensors are required to produce a functional Kv channel by investigating heterotetramers comprising combinations of ful...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1205592109
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
109
Issue:
42
Pages:
16917-16922
Publication date:
2012-10-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:353939
UUID:
uuid:24937f25-e7ac-4ce7-92be-0465373b19e7
Local pid:
pubs:353939
Source identifiers:
353939
Deposit date:
2013-11-17

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