Thesis icon

Thesis

Mechanisms of clinical ototoxicity and inner ear protection

Abstract:

Clinical ototoxicity—permanent hearing loss caused by medications—is estimated to affect millions of patients annually. Two classes of drug are largely to blame: platinum-based chemotherapeutics, primarily cisplatin, and aminoglycoside antibiotics. Development of methods to prevent ototoxicity depends upon an understanding of its mechanisms and may benefit from an understanding of native protective pathways of the inner ear.

As the mechanisms behind cisplatin ototoxicity remain uncl...

Expand abstract

Actions


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Role:
Supervisor
More from this funder
Name:
NIH Oxford-Cambridge Scholars Programs
Funding agency for:
Breglio, A
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:2490cfc1-c58c-4844-b838-0491b6db7dd4
Deposit date:
2017-11-27

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP