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Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization.

Abstract:

In the insulin-secreting beta-cell line beta TC3, stimulation with 11.2 mmol/l glucose caused a rise in the intracellular free Ca2+ concentration ([Ca2+]i) in only 18% of the tested cells. The number of glucose-responsive cells increased after pretreatment of the cells with glucagon-like peptide I (GLP-I)(7-36)amide and at 10(-11) mol/l; 84% of the cells responded to glucose with a rise in [Ca2+]i. GLP-I(7-36)amide induces a rapid increase in [Ca2+]i only in cells exposed to elevated glucose ...

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Publication status:
Published

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Publisher copy:
10.2337/diab.44.7.767

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Journal:
Diabetes
Volume:
44
Issue:
7
Pages:
767-774
Publication date:
1995-07-01
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Source identifiers:
9064

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