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Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress

Abstract:

Since the outbreak of the SARS-CoV-2 pandemic, there have been intense structural studies on purified viral components and inactivated viruses. However, structural and ultrastructural evidence on how the SARS-CoV-2 infection progresses in the native cellular context is scarce, and there is a lack of comprehensive knowledge on the SARS-CoV-2 replicative cycle. To correlate cytopathic events induced by SARS-CoV-2 with virus replication processes in frozen-hydrated cells, we established a unique...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-24887-y

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Author
ORCID:
0000-0002-9210-9139
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Role:
Author
ORCID:
0000-0003-2187-7672
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ORCID:
0000-0002-9814-4285
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ORCID:
0000-0003-3067-9520
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ORCID:
0000-0003-0220-8844
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
12
Issue:
1
Article number:
4629
Publication date:
2021-07-30
Acceptance date:
2021-07-11
DOI:
EISSN:
2041-1723
Pmid:
34330917
Language:
English
Keywords:
Pubs id:
1188791
Local pid:
pubs:1188791
Deposit date:
2021-11-11

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