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Journal article

The immune microenvironment of HPV-negative oral squamous cell carcinoma from never-smokers and never-drinkers patients suggests higher clinical benefit of IDO1 and PD1/PD-L1 blockade.

Abstract:

Background

Never-smokers and never-drinkers patients (NSND) suffering from oral squamous cell carcinoma (OSCC) are epidemiologically different from smokers drinkers (SD). We therefore hypothesized that they harbored distinct targetable molecular alterations.

Patients and methods

Data from The Cancer Genome Atlas (TCGA) (discovery set), Gene Expression Omnibus and Centre Léon Bérard (CLB) (three validation sets) with available gene expression profiles of HPV-negati...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/annonc/mdx210

Authors


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Role:
Author
ORCID:
0000-0002-4271-5093
More from this funder
Name:
French Regional Health Agenc
More from this funder
Name:
French Association for the Development of Dentistry
More from this funder
Name:
French Medical Research Foundation
More from this funder
Name:
Lyon Research Innovation for Cance
More from this funder
Name:
Cancéropôle Lyon Auvergne Rhône-Alpes
Publisher:
Oxford University Press
Journal:
Annals of Oncology More from this journal
Volume:
28
Issue:
8
Pages:
1934-1941
Publication date:
2017-04-01
DOI:
EISSN:
1569-8041
ISSN:
0923-7534
Pmid:
28460011
Language:
English
Keywords:
Pubs id:
pubs:809048
UUID:
uuid:248ac418-2076-4712-91a4-8f1ee45b58fb
Local pid:
pubs:809048
Source identifiers:
809048
Deposit date:
2017-12-11

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