Journal article
HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus.
- Abstract:
-
Early treatment of acute HIV-1 infection followed by treatment interruptions has shown promise for enhancing immune control of infection. A subsequent loss of control, however, allows the correlates of protective immunity to be assessed. Here we show that sudden breakthrough of plasma viraemia occurred after prolonged immune containment in an individual infected with HIV-1 at a time when 25 distinct CD8+ T-cell epitopes in the viral proteins Gag, RT, Integrase, Env, Nef, Vpr, Vif and Rev were...
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- Publisher copy:
- 10.1038/nature01200
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Bibliographic Details
- Journal:
- Nature
- Volume:
- 420
- Issue:
- 6914
- Pages:
- 434-439
- Publication date:
- 2002-11-05
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- URN:
-
uuid:248a78e7-58b1-4094-8c39-169f9c1eaec6
- Source identifiers:
-
191126
- Local pid:
- pubs:191126
Item Description
Terms of use
- Copyright date:
- 2002
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