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HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus.

Abstract:

Early treatment of acute HIV-1 infection followed by treatment interruptions has shown promise for enhancing immune control of infection. A subsequent loss of control, however, allows the correlates of protective immunity to be assessed. Here we show that sudden breakthrough of plasma viraemia occurred after prolonged immune containment in an individual infected with HIV-1 at a time when 25 distinct CD8+ T-cell epitopes in the viral proteins Gag, RT, Integrase, Env, Nef, Vpr, Vif and Rev were...

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Publisher copy:
10.1038/nature01200

Authors


Altfeld, M More by this author
Johnston, MN More by this author
Agrawal, D More by this author
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Journal:
Nature
Volume:
420
Issue:
6914
Pages:
434-439
Publication date:
2002-11-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:248a78e7-58b1-4094-8c39-169f9c1eaec6
Source identifiers:
191126
Local pid:
pubs:191126

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