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Journal article

Dose and fractionation in radiotherapy of curative intent for non-small-cell lung cancer: Meta-analysis of randomized trials

Abstract:
We conducted a meta-analysis of overall survival in 3,795 patients with non-smallcell lung cancer who were randomized in 21 trials comparing higher versus lower radiotherapy doses of curative intent. In trials with chemotherapy, higher radiotherapy doses led to poorer survival but, in trials where chemotherapy was not given, higher time-corrected biologically equivalent doses resulted in longer survival. These findings support consideration of further trials of radiotherapy dose escalation within the context of toxicity reduction.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ijrobp.2016.07.022

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More from this funder
Name:
Cancer Research UK
Grant:
C38302/A12981
Publisher:
Elsevier
Journal:
International Journal of Radiation Oncology - Biology - Physics More from this journal
Publication date:
2016-01-01
Acceptance date:
2016-06-16
DOI:
ISSN:
0360-3016
Keywords:
Pubs id:
pubs:637003
UUID:
uuid:24859201-813e-449b-ac96-4c07f5dee51c
Local pid:
pubs:637003
Source identifiers:
637003
Deposit date:
2016-08-02

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