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Low vitamin B12 in pregnancy is associated with adipose-derived circulating miRs targeting PPARγ and insulin resistance

Abstract:

Context

Low vitamin B12 during pregnancy is associated with higher maternal obesity, insulin resistance (IR), and gestational diabetes mellitus. B12 is a key cofactor in one-carbon metabolism.

Objective

We hypothesize that B12 plays a role in epigenetic regulation by altering circulating microRNAs (miRs) during adipocyte differentiation and results in an adverse metabolic phenotype.

Design, Settings, and Main Outcome Measure

Human preadipocyte cell...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1210/jc.2017-01155

Authors


Adaikalakoteswari, A More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics & Gynaecology
ORCID:
0000-0002-6012-2574
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Diabetes Research Fund More from this funder
George Eliot Hospital NHS Trust More from this funder
Medical Research Council More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Clinical Endocrinology and Metabolism Journal website
Volume:
102
Issue:
11
Pages:
4200-4209
Publication date:
2017-09-05
Acceptance date:
2017-08-31
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
Pubs id:
pubs:731818
URN:
uri:248410aa-f437-45f4-b6f8-b4c12305d728
UUID:
uuid:248410aa-f437-45f4-b6f8-b4c12305d728
Local pid:
pubs:731818

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