Journal article
Low vitamin B12 in pregnancy is associated with adipose-derived circulating miRs targeting PPARγ and insulin resistance
- Abstract:
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Context
Low vitamin B12 during pregnancy is associated with higher maternal obesity, insulin resistance (IR), and gestational diabetes mellitus. B12 is a key cofactor in one-carbon metabolism.
Objective
We hypothesize that B12 plays a role in epigenetic regulation by altering circulating microRNAs (miRs) during adipocyte differentiation and results in an adverse metabolic phenotype.
Design, Settings, and Main Outcome Measure
Human preadipocyte cell...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
Actions
Access Document
- Files:
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-
(pdf, 1.1MB)
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- Publisher copy:
- 10.1210/jc.2017-01155
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Authors
Funding
Diabetes Research Fund
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George Eliot Hospital NHS Trust
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Medical Research Council
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Journal of Clinical Endocrinology and Metabolism Journal website
- Volume:
- 102
- Issue:
- 11
- Pages:
- 4200-4209
- Publication date:
- 2017-09-05
- Acceptance date:
- 2017-08-31
- DOI:
- EISSN:
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1945-7197
- ISSN:
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0021-972X
- Pubs id:
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pubs:731818
- URN:
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uri:248410aa-f437-45f4-b6f8-b4c12305d728
- UUID:
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uuid:248410aa-f437-45f4-b6f8-b4c12305d728
- Local pid:
- pubs:731818
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- Vatish et al
- Copyright date:
- 2017
- Notes:
- This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).
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