- Abstract:
-
Context
Low vitamin B12 during pregnancy is associated with higher maternal obesity, insulin resistance (IR), and gestational diabetes mellitus. B12 is a key cofactor in one-carbon metabolism.
Objective
We hypothesize that B12 plays a role in epigenetic regulation by altering circulating microRNAs (miRs) during adipocyte differentiation and results in an adverse metabolic phenotype.
Design, Settings, and Main Outcome Measure
Human preadipocyte cell...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.1mb)
-
- Publisher copy:
- 10.1210/jc.2017-01155
-
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- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Journal of Clinical Endocrinology and Metabolism Journal website
- Volume:
- 102
- Issue:
- 11
- Pages:
- 4200-4209
- Publication date:
- 2017-09-05
- Acceptance date:
- 2017-08-31
- DOI:
- EISSN:
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1945-7197
- ISSN:
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0021-972X
- Pubs id:
-
pubs:731818
- URN:
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uri:248410aa-f437-45f4-b6f8-b4c12305d728
- UUID:
-
uuid:248410aa-f437-45f4-b6f8-b4c12305d728
- Local pid:
- pubs:731818
- Language:
- English
- Keywords:
- Copyright holder:
- Vatish et al
- Copyright date:
- 2017
- Notes:
- This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).
Journal article
Low vitamin B12 in pregnancy is associated with adipose-derived circulating miRs targeting PPARγ and insulin resistance
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Funding
Diabetes Research Fund
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George Eliot Hospital NHS Trust
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Medical Research Council
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